|
Neoplasms
|
0.060 |
AlteredExpression
|
group |
BEFREE |
The clinicopathological significance of Thrombospondin-4 expression in the tumor microenvironment of gastric cancer.
|
31703077 |
2019 |
|
Malignant Neoplasms
|
0.040 |
AlteredExpression
|
group |
BEFREE |
THBS4 expression in cancer-associated fibroblasts (CAFs), normal-associated fibroblasts (NFs) and gastric cancer cell lines was examined by western blotting.
|
31703077 |
2019 |
|
Malignant neoplasm of stomach
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
THBS4 is expressed on CAFs in the gastric cancer microenvironment.
|
31703077 |
2019 |
|
Stomach Carcinoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
THBS4 is expressed on stromal cells with αSMA or Podoplanin expression in the GC microenvironment, but not expressed on cancer cells with cytokeratin expression.
|
31703077 |
2019 |
|
Primary malignant neoplasm
|
0.040 |
AlteredExpression
|
group |
BEFREE |
THBS4 expression in cancer-associated fibroblasts (CAFs), normal-associated fibroblasts (NFs) and gastric cancer cell lines was examined by western blotting.
|
31703077 |
2019 |
|
Neoplasm Metastasis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
THBS4 from CAFs is associated with the metastasis of cancer cells, and is a useful prognostic indicator for gastric cancer patients.
|
31703077 |
2019 |
|
Carcinoma
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Although THBS4 is reportedly frequently expressed in solid tumors, there are few reports of the clinicopathological features of carcinomas with THBS4 expression.
|
31703077 |
2019 |
|
Neuralgia
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
These results provide biochemical evidence that supports a specific role of TSP-4 among the TSPs in mediating the binding to neuronal α<sub>2</sub>δ-1 and suggest that gabapentin does not directly target TSP/α<sub>2</sub>δ-1 interaction to alleviate neuropathic pain.
|
31700036 |
2019 |
|
Malignant tumor of cervix
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In the present study, we confirm 10 differentially expressed miRNAs that could be potential markers or therapeutic targets of cervical cancer. miR-5701 inhibits the proliferation of cervical cancer cells and the expression of its target gene THBS4.
|
31498525 |
2019 |
|
Cervix carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In the present study, we confirm 10 differentially expressed miRNAs that could be potential markers or therapeutic targets of cervical cancer. miR-5701 inhibits the proliferation of cervical cancer cells and the expression of its target gene THBS4.
|
31498525 |
2019 |
|
cervical cancer
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In the present study, we confirm 10 differentially expressed miRNAs that could be potential markers or therapeutic targets of cervical cancer. miR-5701 inhibits the proliferation of cervical cancer cells and the expression of its target gene THBS4.
|
31498525 |
2019 |
|
Diabetes
|
0.010 |
Biomarker
|
disease |
BEFREE |
Thrombospondin-4 increases with the severity of peripheral arterial disease and is associated with diabetes.
|
31227875 |
2020 |
|
Diabetes Mellitus
|
0.010 |
Biomarker
|
group |
BEFREE |
Thrombospondin-4 increases with the severity of peripheral arterial disease and is associated with diabetes.
|
31227875 |
2020 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Interestingly, TSP-4 levels were higher in patients with type 2 diabetes mellitus or prediabetes (DGT) compared with normal glucose tolerance (NGT) (4.76 ± 0.42 vs. 4.66 ± 0.41, p = 0.035).
|
31227875 |
2020 |
|
Peripheral Vascular Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Thrombospondin-4 increases with the severity of peripheral arterial disease and is associated with diabetes.
|
31227875 |
2020 |
|
Prediabetes syndrome
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Interestingly, TSP-4 levels were higher in patients with type 2 diabetes mellitus or prediabetes (DGT) compared with normal glucose tolerance (NGT) (4.76 ± 0.42 vs. 4.66 ± 0.41, p = 0.035).
|
31227875 |
2020 |
|
Peripheral Arterial Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
TSP-4 (ng/ml) was measured in 365 PAD patientsusing a commercially available ELISA.
|
31227875 |
2020 |
|
Myocardial Infarction
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
None of studied single genetic variants-F13A1 Val34Leu, THBS2 T/G 3'UTR and THBS4 Ala387Pro-and the extended CC/TT/GG haplotype of F13A1/THBS2/THBS4 genes was associated with MI in young age.
|
30972713 |
2019 |
|
Middle Cerebral Artery Occlusion
|
0.010 |
Biomarker
|
disease |
BEFREE |
Using a rat permanent middle cerebral artery occlusion (MCAO) model, the effect of TSP4-overexpressing BMSCs on the regeneration of blood vessels was systematically tested by the neurological function score, immunohistochemistry and immunofluorescence staining assays.
|
30947736 |
2019 |
|
Malignant Neoplasms
|
0.040 |
AlteredExpression
|
group |
BEFREE |
The aim of this study was to study THBS4 expression in hepatocellular carcinoma (HCC) and determine if it was a prognostic marker for this malignancy.
|
30802535 |
2019 |
|
Primary malignant neoplasm
|
0.040 |
AlteredExpression
|
group |
BEFREE |
The aim of this study was to study THBS4 expression in hepatocellular carcinoma (HCC) and determine if it was a prognostic marker for this malignancy.
|
30802535 |
2019 |
|
Liver carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
THBS4 expression was higher in HCCs than in matched para-cancerous tissues (P < 0.001).
|
30802535 |
2019 |
|
Liver Cirrhosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Additionally, subgroup analysis showed that high THBS4 levels were only associated with poor overall survival for alpha-fetoprotein >40 ng/mL (P = 0.028) and cirrhosis (P = 0.002).
|
30802535 |
2019 |
|
Cirrhosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Additionally, subgroup analysis showed that high THBS4 levels were only associated with poor overall survival for alpha-fetoprotein >40 ng/mL (P = 0.028) and cirrhosis (P = 0.002).
|
30802535 |
2019 |
|
Malignant Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
Further, the bioinformatics analysis of the cancer genome atlas dataset suggested that there may be a positive correlation between THBS4 and KLF9 expression.
|
30746617 |
2019 |